The Acid Fast Club

Bringing the UK's mycobacteria research community together

Author: neilstoker

  • AFC Winter 2016 meeting

    AFC Winter 2016

    Held at the London School of Hygiene & Tropical Medicine

    Friday January 8th 2016

    Scientific Programme

    Session 1 (Welcome, Host presentations and Offered papers)

    The TB Centre at the London School of Hygiene & Tropical Medicine – who we are and what we do
    Helen Fletcher & Katherine Fielding, London School of Hygiene & Tropical Medicine

    Polyfunctional CD4 T-cells and in vitro mycobacterial growth inhibition detected in Mycobacterium bovis BCG-vaccinated UK infants
    Steven Smith, Andrea Zelmer, Rose Blitz, Helen Fletcher & Hazel Dockrell, London School of Hygiene & Tropical Medicine

    Ex vivo mycobacterial growth inhibition assays (MGIA) as a new tool for assessment of TB vaccines
    Andrea Zelmer, Satria Prabowo, Rachel Tanner, Elena Stylianou, Helen McShane & Helen Fletcher, London School of Hygiene & Tropical Medicine

    The C-terminal domain of protein kinase G is required for regulation of glutamate catabolism in Mycobacterium smegmatis
    Nabanita Bhattacahatyya, M. Zimmerman & H. M. O’Hare, University of Leicester

    Parenteral adenoviral boost enhances BCG-induced protection, but not long-term survival  in a murine model of bovine TB
    Phil Hogarth, Daryan A. Kaveh, M. Carmen Garcia-Pelayo, Paul R. Webb, Esen E. Wooff, Véronique S. Bachy; Animal and Plant Health Agency

    A spatial model of M. tuberculosis in the lung
    Ruth Bowness, Stephen Gillespie & Mark Chaplain, University of St. Andrews

    Session 2 (Offered papers)

    The Suburban Cure–thoughts on dose and genetic susceptibility to TB
    Andrea Cooper & John E. Pearl, University of Leicester

    Does using aerosol and systemic routes of immunisation avoid anti-vector immunity and boost TB vaccine responses?
    Zita-Rose Manjaly Thomas, Iman Satti, Stephanie Harris, Joel Meyer, Morven Wilkie, Michael Riste, Ali Hamidi, Sharon Sheehan, Alice Minhinnick, Henry Bettinson & Helen McShane, University of Oxford

    Investigating host regulatory pathways that limit immunopathology in tuberculosis
    Patience T. Brace, LB Tezera, JS Friedland, TM Millar, CG Proud & PT Elkington, University of Southampton

    Towards definition of an immunological basis of protection obtained by prime-boost immunisation against bovine tuberculosis
    Hannah Metcalfe, Bernardo Villarreal-Ramos, Gareth J. Jones, Sabine Steinbach, W. Ivan Morrison , Tom Connelley & Martin Vordermeier, Animal and Plant Health Agency

    Targeting the mycobacterial membrane using novel antimicrobial peptides for tuberculosis therapy
    Jasmeet Singh Khara, SM Newton, N Krishnan, I Uhra, M Priestman, PR Langford, PLR Ee & BD Robertson, Imperial College

    Circulating serum microRNAs as novel biomarkers for bovine tuberculosis
    Carolina N.Correia, Nicolas C. Nalpas, Kirsten E. McLoughlin, David A. Magee, Ronan G. Shaughnessy, John A. Browne, Adam O. Whelan, H. Martin Vordermeier, Eamonn Gormley, Bernardo Villarreal-Ramos, Stephen V. Gordon & David E. MacHugh, University College Dublin

    Objectively-measured coughing patterns in pulmonary tuberculosis
    Richard Turner, Graham Bothamley & Surinder Birring, Homerton University Hospital NHS Foundation Trust

    Programme details (Word file)

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  • AFC Winter 2015 meeting

    AFC Winter 2015

    Held at The National Institute for Medical Research, London

    January 9th 2014

    Scientific Programme

    Session 1 (History of AFC and Offered papers)

    A brief history of the Acid Fast Club
    Ann Rawkins. Public Health England, Porton Down

    Toll-like receptor and inflammasome mediated response in HIV-tuberculosis-associated immune reconstitution inflammatory syndrome
    Rachel PJ Lai, Graeme Meintjes, Katalin A Wilkinson, Christine M Graham, Suzaan Marais, Helen Van der Plas, Armin Deffur, Charlotte Schutz, Chloe Bloom, Indira Munagala, Esperanza Anguiano, Rene Goliath, Gary Maartens, Jacques Banchereau, Damien Chaussabel, Anne O’Garra & Robert J Wilkinson. Division of Mycobacterial Research, MRC National Institute for Medical Research

    Role of Rab20 during Mycobacterium tuberculosis phagosome trafficking
    Laura Schnettger, Gang Pei & Maximiliano G. Gutierrez
    Mycobacterial Research, MRC National Institute for Medical Research

    M. tuberculosis dysregulates vitamin D metabolism
    Karolina D Witt, Zhican Wang, Kashaf Junaid, Anna K Coussens, David A Jolliffe, Robert J Wilkinson, Kenneth E Thummel & Adrian R Martineau. Queen Mary University of London.

    Investigating the role of hepcidin and iron metabolism in a murine model of Mycobacterium tuberculosis infection
    Rachel Harrington-Kandt, Elena Stylianou, Hal Drakesmith & Helen McShane. Jenner Institute, University of Oxford

    The role of nitric oxide in the production of Rpf-dependent mycobacteria
    Sarah Glenn, Obolbek Turapov, Vadim Marakov, Bavesh Kana, Peter Andrew & Galina Mukamolova. Department of Infection, Immunity and Inflammation, University of Leicester

    Session 2: Offered papers and Douglas Young

    Primary human airway epithelial cells are early responders to tuberculosis infection
    Ann-Katrin Reuschl, M Edwards, D Connell, N Siddiqui, H Lambie, S Bremang, OM Kon, R Shattock & A Lalvani. Tuberculosis Research Centre, NHLI, Imperial College London

    Helminth induced CD4+FoxP3+ T cells are associated with an impaired immune response to Mycobacterium tuberculosis
    Frederic Toulza, Lilian Tsang, Michael Brown & Hazel Dockrell; London School of Hygiene and Tropical Medicine

    Phenotypic resistance in mycobacteria is associated with the presence of lipid bodies not age of cells
    Robert Hammond, Han Xiao, Katarina Orvacova & Stephen Gillespie. School of Medicine, University of St.Andrews

    Pathogenic mycobacteria achieve cellular persistence by inhibiting the Niemann-Pick type C disease cellular pathway
    Paul Fineran, E. Lloyd-Evans, N. A. Lack, N. Platt, L. C. Davis, A. J. Morgan, R. Tatoturi, D. Kelly, S. Clark, A. Williams, I. Williams, W. Tynan, N. Al Eisa, A. Galione, D. Ory, D. Russell, M. Brenner, E. Sim & F. M. Platt. Department of Pharmacology, University of Oxford

    Molecular profiling of the tuberculin skin test reveals diverse effects of HIV-1 infection in active tuberculosis
    Lucy CK Bell, Gabriele Pollara, Mellissa Pascoe, Gillian Tomlinson, Rannakoe J. Lehloenya, Richard Meldau, Paul Elkington, Robert Miller, Alan Ramsey, Benjamin Chain, Keertan Dheda & Mahdad Noursadeghi

    Mill Hill and the Acid Fast Club
    Douglas Young. NIMR/Crick

    Programme details (Word file)

  • AFC Summer 2015 meeting

    Friday 3rd July 2015

    at the University of Birmingham, Birmingham B15 2TT

    (Local Organiser: Luke Alderwick)

    Call for abstracts

    Offered papers should be sent on this form to the meetings secretary, Tine Arnvig (k.arnvig <AT> ucl.ac.uk) no later than Friday 24th April.  All papers should include the title, affiliation of each author and a short summary (no more than 100 words). Papers cannot be considered after the club’s committee meeting.

    Nominations for new members may also be sent to Tine Arnvig. Please provide the name of the nominating and seconding members and the full contact details of the proposed member no later than Friday 24th April.

    Remember that if you nominate a new member you should expect to attend the meeting!

  • AFC History presentation July 2014

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    A presentation by Ann Rawkins, at the AFC’s 60th anniversary meeting held in Berlin, July 2014.

  • AFC Winter 2014 meeting

    AFC Winter 2014

    Held at Birkbeck College, London

    January 10th 2014

    Scientific Programme

    Session 1

    NSAIDs to tackle drug resistance in Mycobacterium tuberculosis
    Arundhati Maitra, Dimitrios Evangelopoulos, Parisa Nakhostin Mortazavi, Aleksei Kovalev, Juan David Guzman, Timothy D. McHugh and Sanjib Bhakta. Mycobacteria Research Laboratory, Institute of Structural and Molecular Biology, Department of Biological Sciences, Birkbeck College

    Structure and Function of the mycobacterial ACG protein family
    Nicholas H. Keep, Francois Xavier-Chauviac, Doris Quay, James Torpey, Martin Bommer, Ambrose Cole. Institute for Structural and Molecular Biology, Crystallography, Dept of Biological Sciences, Birkbeck College

    Innate and antigen-specific cytotoxic cells and paradoxical HIV-1-associated tuberculosis immune reconstitution inflammatory syndrome (TB-IRIS)
    Katalin A Wilkinson, Naomi F Walker, Graeme Meintjes, Keira H Skolimowska, Kerryn Matthews, Rebecca Tadokera, Ronnett Seldon, Gary Maartens, Mark P Nicol, Molebogeng X Rangaka, Gurdyal S. Besra, Robert J Wilkinson. Clinical Infectious Diseases Research Initiative, Institute of Infectious Disease and Molecular Medicine, and MRC National Institute for Medical Research, London

    High dose rifampicin therapy for a shorter treatment period
    Yanmin Hu, Mitchison DA, Jindani A, Liu Y, Coates ARM. Medical Microbiology, Centre for Infection and immunity, Division of Clinical Sciences, St George’s, University of London

    Getting to know Mycobacterium tuberculosis through metabolomics
    Gérald Larrouy-Maumus, and Luiz Pedro Sório de Carvalho. Division of Mycobacterial Research, MRC National Institute for Medical Research, London

    Session 2

    Counting mycobacteria: how many beans make five?
    Han Xiao, Katarina Oravcova, Wilber Sabiiti, Eoghan Farmer, Stephen Gillespie. School of Medicine, University of St.Andrews

    The pathological role of neutrophil necrosis in tuberculosis
    David M Lowe, Nonzwakazi Bangani, Katalin A Wilkinson, Robert J Wilkinson, Adrian R Martineau. Department of Medicine, Imperial College London, and Clinical Infectious Diseases Research Initiative, Institute for Infectious Diseases and Molecular Medicine, University of Cape Town, Observatory 7925, Cape Town, South Africa

    Role of lymph node-derived lymphatic endothelial cells in mycobacterial Infection
    Maximiliano G. Gutierrez. National Institute of Medical Research, Mill Hill, London

    Recovery of TB genomes from metagenomes
    Jacqueline Chan, Martin Sergeant, Andrew Millard, Elizabeth Wellington, Helen Donoghue and Mark Pallen. Warwick Medical School, University of Warwick

    Bioelectrospray-based cell encapsulation for in vitro modelling of Mycobacterium tuberculosis induced granuloma formation
    Liku B Tezera, Magda K Bielecka, Victoria Workman, Patience T Brace, Brian D Robertson, Suwan N Jayasinghe, Paul T Elkington. Clinical and Experimental Sciences, Faculty of Medicine, University of Southampton

    Programme details (Word file)

  • AFC Summer 2013 meeting

    AFC Summer 2013

    Held at University College, Dublin

    July 4th-5th 2013

    Scientific Programme

    Session 1: University College Dublin Symposium and guest speakers

    Guest speaker
    Prof Patrick Brennan, Colorado State University

    Host preference across the Mycobacterium tuberculosis complex
    Stephen Gordon, University College Dublin

    Wildlife intervention strategies for control of bovine tuberculosis
    Eamonn Gormley, School of Veterinary Medicine, UCD, Dublin

    Session 2: Trinity College Dublin Symposium and guest speakers

    Invited talk: TB vaccine efficacy trials:what can we learn and what’s next?
    Helen McShane, University of Oxford

    TBC
    Joe Keane, Trinity College Dublin

    Phylogenetic lineages of tuberculosis isolates associate with specific patient demographics in New Zealand
    Ronan F O’Toole, Trinity College Dublin

    The ancient evolution of tuberculosis as a zoonosis
    David E Minnikin, University of Birmingham, Birmingham

    Session 3: Offered papers

    TBC
    David McHugh, University College Dublin

    Genetic Analyses of a Conserved Virulence Regulon in the Mycobacterium tuberculosis complex
    Claire Healey, University College Dublin

    The Synthesis and Biological Evaluation of Mycobacterial p-Hydroxybenzoic Acid Derivatives (p-HBADs)
    Eoin Sacnlan, Trinity College Dublin

    My-D88 adapter like (Mal) is required for effective macrophage responses To Mycobacterium tuberculosis
    Cliona Ni Cheallaigh, Trinity College Dublin

    Insights into the global metabolic changes in mycobacteria during nitrogen stress
    Kerstin Williams, Imperial College London

    Session 4: Offered papers

    Biofilms and antibiotic tolerance: transcriptomic profiles of Mycobacterium smegmatis biofilms
    S.A. Lethbridge, Public Health England, Porton Down, Salisbury

    Genome-wide mapping of transcription start sites defines an extensive leaderless transcriptome in Mycobacterium tuberculosis
    Teresa Cortes,National Institute for Medical Research, MRC, London

    A transposon-mutagenesis library to study mechanisms of drug resistance in Mycobacterium tuberculosis
    Joana Fonseca, University College London

    Mannan core branching of lipo(arabino)mannan is required for initiation of mycobacterial granuloma formation in vivo
    Arun K. Mishra, MRC National Institute of Medical Research, London

    Mycobacterium leprae – A genome lost in time
    Thomas A. Mendum, University of Surrey

  • AFC Winter 2013 meeting

    AFC Winter 2013

    Held at the Royal Free Hospital, London

    January 11th 2013

    Scientific Programme

    Session 1

    Human plasma miRNA and snoRNA molecules are significantly downregulated in tuberculosis-infected individuals in response to chemotherapy but HIV-1 co-infection spoils the picture
    Isobella Honeyborne, Shirin Bokari, Silvana Christou, Clare Eckold, Alexander Pym, Timothy McHugh. UCL, London

    Carbon fixation and a mixed diet for intracellular Mycobacterium tuberculosis
    Dany J V Beste, Katharina Nöh, Sebastian Niedenführ, Tom A Mendum, Nathaniel D Hawkins, Jane L Ward, Michael H Beale, Wolfgang Wiechert and Johnjoe McFadden. Faculty of Health and Medical Sciences, Department of Microbial and Cellular Sciences, University of Surrey

    Destruction of lung extracellular matrix by MMP-1 is critical in TB pathogenesis
    Basim Al shammari, Takayuki Shiomi, Liku Tezera, Brian D Robertson, Jon S Friedland, Jeanine D’Armiento and Paul Elkington. Department of Infectious Diseases and Immunity, Imperial College London

    Non-replicating Mycobacterium tuberculosis elicits a reduced pathogenicity profile and corresponding modifications to the cell wall
    Bacon J, Alderwick LJ, Allnutt JA, Gabasova E, Watson R, Hatch KA, Clark SA, Marriott A, Rayner E, Tolley H, Pearson G, Hall G, Besra GS, Wernisch L, Williams A, Marsh PD. Health Protection Agency, Porton Down, Salisbury

    Analysis of host gene induction following MVA85A
    M. Matsumiya, Z. Lang, J. Meyer, S. Harris, A. Pathan, R. Rowland, A. Minassian, H. Fletcher, H. McShane. The Jenner Institute, University of Oxford

    Session 2

    MTS2048 a small RNA with a secret
    Joanna Houghton, Olga Schubert, Douglas Young and Kristine Arnvig. Division of Mycobacterial Research, MRC National Institute for Medical Research, Mill Hill, London

    Structure of M. tuberculosis DprE1, the target of BTZ compounds
    Sarah M Batt, Talat Jabeen, Veemal Bhowruth, Peter A Lund, Luke J Alderwick, Klaus Fütterer, Gurdyal S Besra. School of Biosciences, University of Birmingham

    Discovery of the anti-tubercular specific activity of ibuprofen and other 2-arylpropanoic acids using the HT-SPOTi whole-cell phenotypic assay
    Juan David Guzman, Dimitrios Evangelopoulos, Antima Gupta, Kristian Birchall, Solomon Mwaigwisya, Simon Gibbons, Barbara Saxty, John Malkinson, Timothy D. McHugh and Sanjib Bhakta. Mycobacteria Research Laboratory, Institute of Structural and Molecular Biology, Department of Biological Sciences, Birkbeck College, London

    Selective ESAT6-dependent necrosis of phosphatidylserine externalised neutrophils
    Robert J Francis, Rachel E Butler, Graham Stewart. Department of Microbial and Cellular Sciences, Faculty of Health and Medical Sciences, University of Surrey

    Ethnic variation in inflammatory profile in tuberculosis
    Adrian R. Martineau, Anna K. Coussens, Robert J. Wilkinson, Vladyslav Nikolayevskyy, Francis A. Drobniewski, Paul T. Elkington, Graham H. Bothamley, Robert N. Davidson, Christopher J. Griffiths. Queen Mary University of London, Barts and The London School of Medicine and Dentistry, Blizard Institute, London E1 2AB, Division of Mycobacterial Research, MRC National Institute for Medical Research, London

  • AFC Summer 2012 meeting

    AFC Summer 2012

    Held at the Brighton and Sussex Medical School, University of Sussex

    July 5th-6th 2012

    Scientific Programme

    Session 1: Brighton and Sussex Medical School and University ofSussex Symposium

    Genetic susceptibility to M.tuberculosis
    Melanie Newport

    Interactions between a novel transcriptional activator and RNA polymerase
    Mark Paget

    Flow-cytometry in the diagnosis of active TB
    Florian Kern

    DNA repair in mycobacteria
    Aidan Doherty

    The effect of growth rate on the efficacy of isoniazid against Mycobacterium tuberculosis
    Alice Marriott, Jon Allnutt, Kim Hatch, Catherine Arnold, Tim McHugh, Philip Marsh, Joanna Bacon, HPA Microbiology Services, Porton Down, Salisbury

    Session 2: Guest speaker

    Host-pathogen interactions in TB
    Olivier Neyrolles. CNRS, Toulouse

    Session 3: Offered papers

    Evaluating BCG and novel TB vaccine candidates with a human BCG challenge model
    Joel Meyer, S Harris, I Satti, A Minassian, H Fletcher, H McShane, Jenner Institute, Oxford University

    Does biofilm growth of Mycobacterium tuberculosis replicate features of the phenotypes observed in tuberculous sputum?
    Abdulwhab Binjomah, Andrew Bell, Su-Min Lee, Galina Mukamolova, Natalie Garton and Mike Barer, Department of Infection Immunity and Inflammation, University of Leicester

    The role of peptidoglycan glycolylation in mycobacterial dormancy and resuscitation
    Jessica Loraine, Obolbek Turapov, Jacob Biboy, Waldemar VollmerandGalina Mukamolova, Infection, Immunity, Inflammation Department and Chemistry Department, University of Leicester

    Transcriptional profiling of disease-induced host responses in bovine tuberculosis
    Elihu Aranday-Cortes, Philip J. Hogarth, Daryan A. Kaveh, Adam O. Whelan, Bernardo Villarreal-Ramos, Ajit Lalvani, H. Martin Vordermeier, Animal Heath & Veterinary Laboratories Agency, Surrey

    Measuring phosphorylation of the metabolic regulator GarA in living mycobacteria
    Barbara Rieck, A. R. Bottrill, H M O’Hare, Department of Infection, Immunity, and Inflammation, University of Leicester

    Session 3: Offered papers

    Genome-wide mapping of the GlnR regulon in Mycobacterium smegmatis
    Victoria Jenkins, Brian Robertson and Kerstin Williams, MRC CMBI, Flowers Building, Imperial College London, South Kensington, London

    Identification of novel Mt-GuaB2 inhibitor series active against M. tuberculosis
    Veeraraghavan Usha, Judith V. Hobrath, Sudagar S. Gurcha, Robert C. Reynoldsand Gurdyal S. Besra, School of Biosciences, University of Birmingham, Edgbaston, Birmingham

    ATP-dependent Mur ligases in the biogenesis of cell wall peptidoglycan in Mycobacterium tuberculosis: novel targets for anti-TB drug discovery
    Tulika Munshi, Antima Gupta, Dimitrios Evangelopolous, Juan David Guzman, Nicholas H. Keep, Simon Gibbons and Sanjib Bhakta, Mycobacteria Research Laboratory, Department of Biological Sciences, Institute of Structural & Molecular Biology, Birkbeck, University of London

    Impaired host immune system favours tuberculosis induced by Mycobacterium africanum but not Mycobacterium tuberculosis
    Leopold. D. Tientcheu, J. Sutherland, B. de Jong, S. Smith, H. M. Dockrell, M. O. Ota, Vaccinology Theme, Medical Research Council Unit The Gambia, and Department of Immunology and Infection, Faculty of Infectious and Tropical Disease, London School of Hygiene & Tropical Medicine

  • AFC Winter 2012 meeting

    AFC Winter 2012

    Held at Imperial College, London

    January 6th 2012

    Scientific Programme

    Session 1

    Independent impact of tuberculosis disease stage and HIV co-infection on Mycobacterium tuberculosis (MTB)-specific cellular immunity
    Katrina M Pollock, Montamat-Sicotte D, Cooke G, Kapembwa M, Kon O M, Taylor G P and Lalvani A. Tuberculosis Research Unit, Department of Respiratory Medicine, National Heart and Lung Institute, Imperial College London

    Mycobacterial Growth Indicator Tube (MGIT) assay as a correlate of protection against TB
    Leanne Marsay, R. Tanner, H. Poyntz, K. Griffiths, E. Stylianou, M. Kostov, H. Fletcher, S. Sharpe, H. McShane. The Jenner Institute, University of Oxford, Oxford, UK

    Increased diagnostic yield of sputum samples for Mycobacterium tuberculosis by loop mediated amplification (LAMP) compared to sputum microscopy in Kerbala, Iraq
    Mohanad Ahmed, Hassan Abood, Natalie Garton and Mike Barer.West Euphrates Research Unit, Kerbala University, Kerbala, Iraq

    Evaluation of the influence of the route of administration in the immunogenicity of Ad5-Ag85A as booster in BCG vaccinated cattle
    Adam Whelan, Pinar Court, Glyn Hewinson, Xhou Zing, Derek Clifford, Martin Vordermeier, Bernardo Villarreal-Ramos. TB Research Group, Animal Health and Veterinary Laboratories Agency, Surrey

    A TetR-type regulator represses the production of oleic acid in mycobacteria
    Mahmudul Hasan Sikder, Mike Withers, Ricardo Balhana, Neil Stoker and Sharon Kendall. Department of Pathology and Infectious Diseases, The Royal Veterinary College, London

    Session 2

    Vitamin D accelerates resolution of inflammatory responses during tuberculosis treatment
    Anna KCoussens, Hanifa Y, Nikolayevskyy V, Elkington PT, Islam K, Timms PM, Venton TR, Bothamley GH, Packe GE, Darmalingam M, Davidson RN, Milburn HJ, Baker LV, Barker RD, Mein CA, Bhaw-Rosun L, Nuamah R, Young DB, Drobniewski FA, Griffiths CJ, Wilkinson RJ, Martineau AR. Division of Mycobacterial Research, MRC National Institute of Medical Research, London

    Expression of the two ClpP protease subunits in Mycobacterium tuberculosis
    Yoann Personne, Amanda C. Brown, Tanya Parish. Barts and London School of Medicine and Dentistry, Queen Mary University of London

    Phthiocerol dimycocerosate waxes are potential biomarkers for the rapid diagnosis of tuberculosis in sputum
    David E. Minnikin, Ruth McNerney,Denise M. O’ Sullivan, Simona C. Nicoara, Elizabeth L. Corbett, Reggie Mutetwa, Stanley Mungofa, Oona Y-C. Lee, Max W. Bardwell, Geraint H. Morgan. School of Biosciences, University of Birmingham

    Systems pharmacology approach to antimycobacterial drug discovery. Luiz Pedro S. de Carvalho and Douglas Young. Division of Mycobacterial Research, MRC National Institute for Medical Research, Mill Hill, London

    Serodiagnosis of tuberculosis: due to change track
    Juraj Ivanyi. Guy’s Campus of Kings College London

  • AFC Summer 2011 meeting

    AFC Summer 2011

    Held at the University of Surrey

    July 8th 2011

    Scientific Programme

    Session 1: Surrey University

    Interrogating transcriptomic data with a genome-scale model of metabolism: what does M. tuberculosis eat in vivo?
    Bhushan Bonde, Dany Beste, Emma Laing, Andrzej M. Kierzek, Johnjoe McFadden

    Cell death fates in Mycobacteruim tuberculosis infected             macrophages are influenced by multiplicity of infection, virulence, and strain characteristics
    Rachel E. Butler, Priscille Brodin, Jichan Jang, Mi-Seon Jang, Hilde Smith, Jelle Thole, Brigitte Gicquel, Olivier Neyrolles and Graham R Stewart

    Session 2

    Exploring the therapeutic potential of a novel human IgA antibody against tuberculosis
    Rajko Reljic, Sucharitha Balu, Jenny Woof and Juraj Ivanyi. St George’s, University of London

    Genome Scale Modelling of Mycobacterium bovis and Mycobacterium bovis Bacille Calmette-Guérin
    Emma Lofthouse, Paul Wheeler, Andrzej Kierzek, Dany Beste, Tom Mendum and Johnjoe McFadden. Tuberculosis Research Group, Animal Health and Veterinary Laboratories Agency,Weybridge

    An evaluation of the safety and immunogenicity of MVA85A delivered by aerosol to the lungs of macaques
    A.D. White, K. Gooch, L. Sibley, M.J. Dennis, G. Betts, A. Reyes-Sandoval, A. Williams, P.D. Marsh, H. McShane, S.A. Sharpe. Health Protection Agency, Centre for Emergency Preparedness and Response, Porton Down, Salisbury

    Broad cytokine/chemokine response in peripheral blood stimulated with heparin-binding haemagglutinin following BCG vaccination of UK infants
    Steven G. Smith, Sophie Lecher, Rose Blitz, Camille Locht, Hazel M. Dockrell. Department of Immunology and Infection, London School of Hygiene & Tropical Medicine, London

    The use of low temperature incubation to screen for whole cell activity of drugs against persisters
    D.Coleman, D.A.Mitchison, S Waddell, St Georges, University of London

    Session 3

    Mycobacterium leprae upregulates human beta defensins in cutaneous leprosy Type 1 Reactions
    Anna L. Cogen, Steven L. Walker, Chrissy Roberts, Sushmita Dhakal, Rachel A. Hawksworth, Kishori Mahat , Diana N.J. Lockwood. Faculty of Infectious Tropical Diseases, Department of Clinical Research, London School of Hygiene and Tropical Medicine, London

    Mycobacterium tuberculosis lineage influences innate immune response and is associated with distinct cell envelope lipids
    Nitya Krishnan, Wladimir Malaga, Maxine Caws, Douglas.B.Young, Brian D. Robertson, Christophe Guilhot, Guy.E.Thwaites. Centre for Molecular Microbiology and Infection, Imperial College, London

    The C-Terminal Domain of the Ethambutol target Mt-EmbC is a Lectin-like Carbohydrate Binding Module
    Luke J. Alderwick, Georgina S. Lloyd, Hemza Ghadbane, John W. May, Apoorva Bhatt, Lothar Eggeling, Klaus Fütterer, Gurdyal S. Besra. School of Biosciences, University of Birmingham

    A distinct profile of cytokine production correlates with and predicts BCG induced protection in a Mycobacterium bovis murine challenge model
    Daryan A. Kaveh, Elihu Aranday-Cortes and Philip J. Hogarth, TB Research Group, Animal Health and Veterinary Laboratories Agency, Weybridge, Surrey

    Insights into immigrant screening for tuberculosis from evaluation of practice and a multi-centre cohort study of cost-effectiveness
    Manish Pareek, John P. Watson, L Peter Ormerod, Onn Min Kon, Gerrit Woltmann, Peter J White, Ibrahim Abubakar, Geoffrey P Garnett, Ajit Lalvani, Tuberculosis Research Unit, National Heart and Lung Institute, Imperial College London, UK & Department of Infectious Disease Epidemiology, Imperial College London, UK