UNIVERSITY OF SURREY JULY 2023

AFC Summer meeting 2023

6th July 2023

Programme of speakers, associates, affiliations and presented titles

(Speakers indicated in Bold)

Welcome by AFC Chair, Tim McHugh

Session 1: Host session

Introduction from the host institute.: An overview of TB work at University of Surrey.

Graham Stewart.

University of Surrey.

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Inhibition of Sec61 by mycolactone as a central mechanism of Buruli ulcer
disease.

Rachel Simmonds.

University of Surrey

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Fluxomic analysis of host metabolism in TB.

Kushboo Borah Slater, Tiffany Xu, Luciana Rodrigues, Brian Robertson, Johnjoe McFadden.

University of Surrey

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Understanding antibiotic penetration into mycobacterial biofilms using NanoSIMS.

Winifred Akwani, Ian Gilmore, Paulina Rakowska, Mark Chambers, Greg McMahon, Suzie Hingley-Wilson.

University of Surrey

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Single-cell metabolomics: Understanding cellular heterogeneity and the interaction between Mycobacterium tuberculosis and its host.

Abigail Cook and George Mayson.

University of Surrey

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Building Communities with the Microbiology Society.

Dany Beste.

University of Surrey

Session 2: Selected papers from submitted abstracts

Different tuberculosis vaccines and their components induce distinct cytokine signatures.

Egle Butkeviciute, Helen McShane, Rajko Reljic, Mario Flores-Valdez, Michel de Jesús Aceves-Sánchez, Christine Jones, Steven Smith, Hazel Dockrell.

London School of Hygiene and Tropical Medicine

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Determining the architecture of the Mycobacterium tuberculosis MCE4 cholesterol transporter complex.

Joshua Ari Kaplan, Katherine Fenn, Chi Tung, Wong, Isha Mohan, Maha Alharpi, Miklos Kralik, Camila Suarez, Ruth Rose, Vidya Chandran Darbari.

Queen Mary University of London

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The repression of efpA in M. tuberculosis reduces viability and prevents regrowth following isoniazid exposure.

Adam Roberts, Chris Moon, Valwynne Faulkner, Sharon Kendall, Simon Waddell, Joanna Bacon.

UK Health Security Agency

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Adaptive immune responses to aerosolised Bacillus Calmette-Guérin (BCG) as a surrogate controlled human infection model for Mycobacterium tuberculosis.

Hazel Morrison, Iman Satti, Stephanie A. Harris, Julia Marshall, Susan Jackson, Shuailin Li, Raquel Lopez Ramon, Celia Mitton, Robert Mitchell, Alberta Ateere, Andrew Mawer, Timothy Fredsgaard-Jones, Marco Polo Peralta Alvarez, Rachel Tanner, Hannah Scott, Ingrid Cabrera Puig, Rebecca Powell-Doherty, Henry Bettinson, Timothy Hinks, Helen McShane.

University of Oxford

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Testing a novel, self-adjuvanting mucosal vaccine candidate for TB in the mouse model of infection.

Andy Tran, Rajko Reljic, Andrea Cooper, Mi Young Kim, John Pearl, Joseph Vergara.

St. George’s University of London.

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Surface modulation of mycobacteria by glycoside hydrolases.

Patrick Moynihan, Aaron Franklin, Samuel Benedict, Abigail Layton, Elisabeth Lowe.

University of Birmingham.

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