AFC Winter meeting 2022
7th January 2022
Programme of speakers, associates, affiliations and presented titles
(Speakers indicated in Bold)
Welcome by AFC Chair, Tim McHugh
Session 1: Host and guest sessions
Structural and functional characterization of two Mycobacterium tuberculosis transporters.
Vivian Tounta, Thomas Meier and Gerald Larrouy-Maumus.
MRC Centre for Molecular Bacteriology and Infection, Imperial College London.
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Comprehensive characterisation of Galleria mellonella as a model for Mycobacterium tuberculosis H37Rv.
Masanori Asai, Yanwen Li, Brian Robertson, Paul Langford, Sandra Newton.
Department of Infectious Disease, Imperial College London.
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Transcriptomic characterization of tuberculous sputum reveals a host Warburg effect and microbial cholesterol catabolism.
Rachel Lai, Teresa Cortes, Suzaan Marais, Neesha Rockwood, Melissa L Burke, Acely Garza-Garcia, Stuart Horswell, Anne O’Garra, Douglas B Young & Robert J Wilkinson.
Imperial College London.
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Catalogue of mutations in M. tuberculosis associated with drug resistance.
Leonid Chindelevitch.
Imperial College London.
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COVID-19 and Tuberculosis – a global tale of hubris and lessons unlearned?
Francis Drobniewski & Salmaan Keshavjee.
Infectious Diseases, Faculty of Medicine, Imperial College London.
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Characterisation of the infant immune system and the influence and immunogenicity of BCG vaccination in infant and adult rhesus macaques.
Charlotte Sarfas, Andrew D. White, Laura Sibley, Alexandra L. Morrison, Jennie Gullick, Steve Lawrence, Mike J. Dennis, Philip D. Marsh, Helen Fletcher & Sally A. Sharpe.
UK Health Security Agency, Porton Down.
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13C15N-Metabolic Flux Analysis quantifies carbon-nitrogen co-metabolism in mycobacteria and identifies glutamate as the central CN node.
Khushboo Borah, Martin Beyß, Ye Xu, Huihai Wu, Jim Barber, Catia Costa, J. Newcombe, Melanie Bailey, Dany Beste, K. Nöh & Johnjoe McFadden.
University of Surrey
Session 2: Selected papers from submitted abstracts
Non-human primate (NHP) responses to aerosol BCG infection.
Emily Hoogkamer, Andrew White, Iman Satti, Sally Sharpe & Helen McShane.
University of Oxford & UK Health Security Agency, Porton Down.
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Nitric oxide treatment induces Resuscitation promoting factor (Rpf)-dependency in Mycobacterium tuberculosis.
Brindha Gap-Gaupool, Sarah M. Glenn, Brindha Gap-Gaupool, Simon Waddell, Joanna Bacon, Marialuisa Crosatti, Sharon Kendall, Olga Riabova, Natalia Monakhova, Jeffrey Green, Obolbek Turapov, Vadim Makarov, Galina V. Mukamolova.
University of Leicester.
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Live dual-fluorescence imaging of host and pathogen acidification uncovers the spatiotemporal dynamics of pyrazinamide action.
Pierre Santucci, Beren Aylan, Laure Botella, Natalia Athanasiadi, Elliott M. Bernard, Claudio Bussi, Enrica Pellegrino and Maximiliano G. Gutierrez
The Francis Crick Institute.
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Whole genome sequencing of Mycobacterium tuberculosis exposed to isoniazid reveals a heterogeneous population of genetic variants.
Christopher Moon, Jordan Pascoe, Rose Jeeves, Charlotte Hendon-Dunn, Jonathan Abrahams, Andrew Preston, Joanna Bacon.
TB Discovery Group, UK Health Security Agency, Porton Down.
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Identifying the genes required for the survival of Mycobacterium bovis in cattle through the use of transposon libraries suggests a role for glycerol phosphate metabolism.
Amanda J Gibson, Jennifer Stiens, Ian J Passmore, Valwynne Faulkner, Josephous Miculob, Sam Willcocks, Stefan Berg,Dirk Werling, Brendan W Wren, Irene Nobeli, Bernardo Villarreal-Ramos, Sharon L Kendall.
Royal Veterinary College.