AFC Summer meeting 2022
30th June and 1st July 2022
Programme of speakers, associates, affiliations and presented titles
(Speakers indicated in Bold)
Welcome by AFC Chair, Tim McHugh
Session 1 (30th June): Host session
An overview of bovine tuberculosis in Wales and the work of the Sêr Cymru
Centre of Excellence for Bovine TB.
Glyn Hewinson.
Aberystwyth University
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The population structure of Mycobacterium bovis in Wales.
Cate Williams, Jessica Friedersdorff, Nicholas Dimonaco, Sarah Seery, Terry Galloway, Richard
Ellis, Paul Schroeder & Glyn Hewinson.
Aberystwyth University and Animal and Plant Health Agency.
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Metabolomic investigations of Mycobacterium bovis infection of cattle.
Richard Pizzey, Jim Scott-Baumann, Manfred Backmann, Bernardo Villarreal-Ramos, Martin Vordermeier, David Rooke, Glyn Hewinson & Luis Mur.
Aberystwyth University, ProTEM Services and Animal and Plant Health Agency.
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Session 2 (30th June): Selected papers from submitted abstracts
Assessment of the frequency of Mycobacterium bovis shedding in the faeces of naturally and experimentally TB infected cattle.
Jason Sawyer, Si Palmer, Gareth A Williams, Colm Brady, Eoin Ryan, Karolina Malczewska, Tim J Bull &
Philip J. Hogarth.
Animal and Plant Health Agency.
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MadR mediates acyl CoA-dependent regulation of mycolic acid desaturation in mycobacteria.
Charlotte Cooper, Eliza J. R. Peterson, Rebeca Bailo, Min Pan, Albel Singh, Patrick Moynihan, Makoto Nakaya, Nagatoshi Fujiwara, Nitin Baliga & Apoorva Bhatt.
University of Birmingham.
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Cellular characteristics of pulmonary granulomas induced by Mycobacterium tuberculosis in two non-human primate models of aerosol infection.
Laura Hunter, F. Javier Salguero, Sally Sharpe, Suzie Hingley-Wilson & Graham Stewart.
UK Health Security Agency & University of Surrey.
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From molecular dynamics to supramolecular properties: the role of PIM lipids in the organisation of the mycobacterial plasma membrane.
Chelsea Brown, Robin A. Corey, Ya Gao, Yeol Kyo Choi, Martine Gileron, Nicolas Destainville, Elizabeth Fullam, Wonpil Im, Phillip J. Stansfeld & Matthieu Chavent.
University of Warwick.
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Incipient tuberculosis is associated with detectable intrathoracic M. tuberculosis infection and low-level bacteraemia in household contacts.
Jee Whang Kim, Karen Bowman, Joshua Nazareth, Joanne Lee, Gerrit Woltmann, Raman Verma, Meedya Sharifpour, Christopher Shield, Catherine Rees, Anver Kamil, Benjamin Swift & Pranabashis Haldar.
University of Leicester.
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Session 3 (1st July): Selected papers from submitted abstracts
Transcriptome analysis of Mycobacterium tuberculosis from murine lung tissue reveals subtle differences between routes of infection and identifies pathways for drug discovery.
Aaron Goff, Jasvir Dhillon, Jamie Medley, Leticia Muraro-Wildner, Phillip D Butcher & Simon J Waddell.
University of Sussex.
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Immunogenicity of BCG revaccination and ChAdOx185A-MVA85A prime-boost in Ugandan adolescents.
Beatrice Nassanga Francis, Anne Wajja, Iman Satti, Agnes Natukunda, Joel Sserubanja, Hazel Morrison, Rebecca Powell-Doherty, Hannah Scott, Emily L. Webb, Helen McShane, Alison Elliott & TB042 trial team.
Makerere University, MRC/UVRI & LSHTM Uganda Research Unit and University of Oxford.
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Novel synergistic anti-tuberculosis combinations of bedaquiline and antimicrobial peptides.
Ye (Tiffany) Xu, Winnie C Akwani, Linda Oyama, Sharon Huws, Suzanne Hingley-Wilson & Johnjoe McFadden.
University of Surrey and Queen’s University Belfast.
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Differentiation of circulating Mycobacterium tuberculosis complex (MTBC) strains in West Africa using molecular assays.
Wellington Owusu, Natalie Riddell, Graham Stewart, Arnoud van Vliet, Augustina Angelina Sylverken &
Suzanne Hingley-Wilson.
University of Surrey and Kwame Nkrumah University of Science & Technology (KNUST), Ghana
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Local coagulopathy in M. ulcerans infection; a new influence in Buruli ulcer disease progression.
Louise Tzung-Harn Hsieh, Jane Newcombe, Tom Mendum, Belinda S. Hall & Rachel E. Simmonds.
University of Surrey.
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Session 4 (1st July): Selected papers from submitted abstracts
Identification of novel indole based PknB inhibitors as anti-tuberculosis agents thought virtual screening, pharmacokinetic predictions and MD simulations.
Pharit Kamsri, Auradee Punkvang, Paptawan Thongdee, Jiraporn Leanpolchareanchai, Sombat Ketrat, Patchreenart Saparpakorn, Supa Hannongbua, Khomson Suttisintong, Prasat Kittakoop, James Spencer, Adrian J. Mulholland, Galina V. Mukamolova & Pornpan Pungpo.
Nakhon Phanom University, Thailand and University of Leicester.
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Synthesis and anti-tubercular activity evaluation of 4-(aryl)oxy-, thio-, sulfoxy-quinoline derivatives targeting the cytochrome bc1 complex.
Robert Murnane, Mire Zloh, Tanya Parish & Federico Brucoli.
De Montfort University.
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In vitro efficacy of relebactam versus avibactam against Mycobacterium abscessus complex.
James Harrison, John A. Weaver, Maya Desai & Jonathan A.G. Cox.
Aston University.
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Identification and evaluation of two conserved M. tuberculosis proteins as potential novel vaccine candidates.
Danai Papakonstantinou, Marisol PerezToledo, Steven J. Dunn, Martin Dedicoat, Alan McNally, Adam F. Cunningham, Matthew K. O’Shea.
University of Birmingham.
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