Category: Meetings

  • AFC Summer 2009 meeting

    AFC Summer 2009

    Held at the Moredun Research Institute, Edinburgh

    July 2nd-3rd 2009

    Scientific Programme

    Session 1: Research at the Moredun

    Johne’s disease: an overview of research at Moredun
    Karen Stevenson, Valerie Hughes, Craig A Watkins, Linda May, Susan Denham, Ian Heron and Joyce McLuckie:

    Corynebacterium pseudotuberculosis – from genome to prevention
    Florence E Pethick, Alex Lainson, Michael C Fontaine

    Session 2

    Phenotype microarray platform: Potential and pitfalls for use with pathogenic mycobacteria
    Bhagwati Uphadyay and Paul R Wheeler. Veterinary Laboratories Agency, Weybridge

    Fast growing, non-infectious and intra-cellularly surviving drug-resistant Mycobacterium aurum: A model for high-throughput anti-TB drug screening
    Antima Gupta, Sanjib Bhakta, Subir Kundu, Manish Gupta, Brahm S. Srivastava, and Ranjana Srivastava. Central Drug Research Institute, India & Birkbeck College, University of London.

    Kinetic Profiling of Immune responses to PE/PPE proteins in M. bovis-infected Cattle
    H.M. Vordermeier, R.G. Hewinson, D.B. Young, S.L. Sampson. VLA Weybridge& Imperial College London

    Session 3

    Life and death in the mycobacterial phagosome
    Rachel Shrimpton, Priscille Brodin, Olivier Neyrolles, Graham Stewart. Division of Microbial Sciences, University of Surrey, UK

    Identification of 2-aminothiazole—4-carboxylate derivatives active against Mycobacterium tuberculosis H37Rv and the ketoacyl-ACP synthase mtFabH
    Qosay Al-Balas, Nahoum G. Anthony, Bilal Al-Jaidi, Amani Alnimir, Grainne Abbott, Alistair K. Brown, Rebecca C. Taylor, Gurdyal. S. Besra, Timothy D. McHugh, Stephen H. Gillespie, Blair F. Johnston, Simon P. Mackay, Geoffrey D. Coxon. University of Strathclyde, Glasgow.

    BCG: surrogate for a human TB challenge?
    Minassian, A, Tchilian, E, Poulton, I, Fletcher, H, Andrews, L,   Poyntz, H, Ronan, E,   Hill, A, & McShane, H. The Jenner Institute, Oxford University

    Acute and persistent Mycobacterium tuberculosis infections depend on the thiol peroxidase Tpx
    Yanmin Hu and Anthony R. M. Coates. St George’s University of London.

     

    Genes and proteins of the nat/hsaD gene cluster and their role in cholesterol metabolism
    Nathan Lack, Dimitrios Evangelopoulos, Sanjib Bhakta, Lindsay Eltis, Areej Abuhammad, Elizabeth Fullam, Edward Lowe and Edith Sim. University of Oxford.

    Session 4

    Structure and functional characterisation of Mycobacterium tuberculosis diaminopimelic acid epimerase (MtDapF)
    Veeraraghavan Usha, Lynn G. Dover, Klaus Fütterer, David L. Roper, Adrian J. Lloyd and Gurdyal S. Besra. University of Birmingham

    The helicase UvrD2 is essential in Mycobacterium tuberculosis
    Alan Williams, Burkhard Springer, Erik C. Böttger, and Elaine O. Davis. NIMR, Mill Hill, London

    Dissection of regenerating T cell responses against tuberculosis in HIV infected adults with latent tuberculosis
    Katalin A. Wilkinson, Ronnett Seldon, Graeme Meintjes, Molebogeng X. Rangaka, Willem A. Hanekom, Gary Maartens, Robert J. Wilkinson. University of Cape Town, South Africa

    Live cell imaging to study growth and cell division in mycobacteria
    Graham Joyce, Kerstin J. Williams, and Brian D. Robertson. Imperial College London

  • AFC Winter 2009 meeting

    AFC Winter 2009

    Held at the NIMR, Mill Hill

    January 9th 2009

    Scientific Programme

    Session 1

    Identification of small RNAs in Mycobacterium tuberculosis
    Kristine B. Arnvig and Douglas B. Young. NIMR, London

    Identification of TB contacts with latent TB infection in a population with a high HIV and TB burden
    Kerry A Millington,Junior Mutsvangwa, Kathryn Chaka, Tafadzwa Mavhudzi, Yin-Bun Cheung, Peter R Mason, , Anthony E Butterworth, Elizabeth L Corbett and Ajit Lalvani. Imperial College, London

    Characterisation of a putative dihydrofolate reductase from Mycobacterium smegmatis
    Dimitrios Evangelopoulos, Nathan Lack, Giles Robertson, Tina Daviter, Nicholas H. Keep, Edith Simand Sanjib Bhakta. Birkbeck College, University of London

    Changes in T cell population dynamics in 3 species: Dynamics of white cell populations in M. tuberculosis infection in rhesus macaques
    K Gooch, S Sharpe, A Williams, M Dennis, P D Marsh. Health Protection Agency, CEPR, Porton Down

    Detection and molecular characterization of 9000-year old Mycobacterium tuberculosis from a Neolithic settlement in the Eastern Mediterranean
    Oona Lee, David Minnikin, Gurdyal Besra, Israel Hershkovitz, Vered Eshed, Ehud Galili, Charles Greenblatt, Eshetu Lemma, Gila Kahila Bar-Gal, Mark Spigelman, Helen Donoghue. University of Birmingham

    Session 2

    Inhibition of phago-lysosome fusion by Mycobacterium bovis BCG induces a Niemann-Pick type C1-like phenotype
    Emyr Lloyd-Evans, Nathan Lack, Edith Sim and Frances M. Platt. University of Oxford

    KstR2: Identification of a second TetR-type regulator involved in cholesterol catabolism in mycobacteria
    Sharon Kendall, Annemieke ten Bokum, Phillipa Burgess, Mike Withers, Iria Uhia Castro, Nwaamaka Owoh, Nadia Mokhtar and Neil Stoker. The Royal Veterinary College, London

    Intranasal vaccination with an ESAT-6 expressing attenuated influenza vaccine
    A. Egorov. AVIR Green Hills Biotechnology, Vienna

    BCG vaccination induces polyfunctional CD4+ T cells in the spleen which correlate with active immunity to a Mycobacterium bovis challenge
    Philip J Hogarth. Veterinary Laboratories Agency, Weybridge.

    The Burden of Mycobacterial Disease in Ethiopian Cattle
    Stefan Berg, Rebuma Firdessa, Endalamaw Gadisa, Meseret Habtamu, Araya Mengistu, Lawrence Yamuah, Gobena Ameni, Brian D. Robertson, Douglas B. Young, Howard Engers, Noel H. Smith, Martin Vordermeier, R. Glyn Hewinson, Abraham Aseffa, and Stephen V. Gordon. Veterinary Laboratories Agency, Weybridge

  • AFC Summer 2008 meeting

    AFC Summer 2008

    Held at the University of Leicester

    July 10th-11th 2008

    Scientific Programme

    Session 1: Leicester-related symposium Part 1
    Overview of TB research at Leicester
    Mike Barer

    Short read sequencing of Mycobacterium tuberculosis
    NJ Loman, GM Weinstock, K Rajakumar, MR Barer & M Pallen.

    Structural and Functional Characterisation of Complexes Formed by ESAT-6/CFP-10 Family Proteins
    Kirsty Lightbody, Dariush Ilghari, Lorna Waters, Vaclav Veverka, Richard Williamson,Philip Renshaw and Mark Carr

    The role of PknG in metabolic regulation in M. tuberculosis
    Helen O’Hare, Rosario Durán, Jens Baumgartner, Marco Bellinzoni, Anne-Marie Wehenkel, Carlos Cervenansky, Pedro Alzari, Kai Johnsson

    Session 2: Leicester-related symposium Part 2
    Studies on lipid bodies of Mycobacterium tuberculosis: Survival of the fattest?
    Su-Min Lee, Galina Mukamolova, Anna Sherratt, Natalie Garton and Mike Barer

    TBIT: A Database for the integrated surveillance and management of tuberculosis cases, latent Tb infection (LTBI) and microbiology
    Gerrit Woltmann, Rob Free, Joanne Malkin and Mike Barer.

    Evaluation of mask sampling and rapid molecular assays in studying the transmission of tuberculosis in Leicester
    Eddy Cheah, Joanne Malkin, Rob Free and Mike Barer

    Session 3: Offered papers

    The Mtb Cytochrome P450 Systems: structural insights and drug targeting
    Kirsty J McLean, Colin Levy, David Leys and Andrew W Munro, University of Manchester

    A simple mutation-based assay for determining the translational start sites of mycobacterial proteins
    Katherine Smollett, Amanda Fivian-Hughes, Anchi Chang and Elaine Davis, MRC National Institute for Medical Research, London

    Relationship of Th1 and FoxP3 positive T cells to the HIV-tuberculosis immune reconstitution inflammatory syndrome
    Graeme A Meintjes, Katalin Wilkinson, Molebogeng Rangaka, Keira Skolimowska, Kerryn van Veen, Musaed Abrahams,Ronnett Seldon, Priscilla Mouton, Dominique J Pepper, Kevin Rebe, Gilles van Cutsem, Mark Patrick Nicol, Gary Maartens, Robert Wilkinson, University of Cape Town, South Africa

    Characterization of a mycobacterial strain that fails to produce mature mycolic acids
    Apoorva Bhatt, University of Birmingham

    Novel Antimycobacterial Agents Targeting Mycolate Synthesis: Are They Pyrazinamide Like?
    Amani Alnimr, Geoff Coxon, Tim McHugh, Stephen Gillespie. Royal Free and University College Medical School

    Session 4: Offered papers

    Oral BCG-Lipid protects from aerogenic M. bovis infection in the guinea pig
    Simon Clark, Frank Aldwell, Martin Cross, Julia Vipond, Yper Hall, Allan Nadian, Ann Williams, Mark Chambers, HPA, CEPR, Porton

    Identification of a crucial branching enzyme in mycobacterial arabinogalactan biosynthesis
    Luke J. Alderwick, Helen L. Birch, Apoorva Bhatt, Doris Rittmann, Karin Krumbach, Albel Singh, Yu Bai, Todd L. Lowary, Lothar Eggeling, and Gurdyal S. Besra, University of Birmingham

    MurE, an ATP dependent ligase in Mycobacterium tuberculosis: recombinant expression, purification and biochemical characterisation
    Chandrakala Basavannacharya, Giles Robertson, Alexis Rubio, Edith Sim, Nicholas Keepand Sanjib Bhakta, Birkbeck, University of London

    Genetic requirements for growth rate modulation during continuous culture in a chemostat
    Dany JV Beste, Bhushan Bonde, Graham Stewart, Claudio Avignone-Rossa, Mike Bushell, Andrzej Kierzek and Johnjoe McFadden, University of Surrey, Guildford

  • AFC Winter 2008 meeting

    AFC Winter 2008

    Held at Barts & The London

    January 11th 2008

    Scientific Programme

    Session 1
    Validating drug targets in Mycobacterium tuberculosis
    David M. Roberts, Paul Carroll, Karen Adie, Tanya Parish. Infectious Disease Research Institute, Seattle, USA

    Unique transcriptome profiles of M.tuberculosis in human sputum
    Simon Waddell, Natalie Garton, Claire Senner, Jason Hinds, Mike Barer and Philip Butcher. St George’s University of London

    Dissecting M.tuberculosis driven signalling pathways in human macrophages causing tissue destruction
    L. Rand, J.A. Green, P.T.G. Elkington, J. S. Friedland. Infectious Diseases and Immunity, Imperial College London

    Rapid differentiation of rifampicin-resistant strains of Mycobacterium tuberculosis
    Kim Mallard, Ghada S. Sharaf Eldon and Ruth McNerney. London School of Hygiene and Tropical Medicine

    Heterogeneity of HupB, an iron-regulated protein of mycobacteria
    Veena C Yeruva, Paul R. Wheeler, Stephen Gordon and Manjula Sritharan. School of Life Sciences, University of Hyderabad, India

    Session 2

    Bystander macrophage apoptosis after Mycobacterium tuberculosis H37Ra infection
    Joseph Keane, Annemieke M.C. ten Bokum, Seonadh M. O’Leary, Deirdre M. Kelly, Mary P. O’Sullivan. Trinity College Dublin and St. James’s Hospital, Dublin, Ireland

    Analysis of a single nucleotide polymorphism in M. bovis BCG
    Debbie M. Hunt, José W. Saldanha, John F. Brennan, Pearline Benjamin, Jeffrey A. Cole, Claire L. Spreadbury and Roger S. Buxton. MRC National Institute for Medical Research.

    Hypervirulence through gene deletion in Mycobacterium tuberculosis
    Annemieke ten Bokum, Farah Movahedzadeh, Rosangela Frita, Sharon Kendall, Debbie Smith, Greg Bancroft and Neil Stoker. London School of Hygiene & Tropical Medicine

    Deletion of hmp gene alters lipid biosynthesis of M. tuberculosis and leads to attenuation of the organism in macrophage and murine infection models
    Yanmin Hu1, Gurdyal S. Besra,2 Sudagar S. Gurcha,2 Manfred Rohde3  Mahavir Singh3 and Anthony Coates1. 1 St George’s University of London, 2 School of Biosciences, The University of Birmingham, 3 Helmholtz Centre for Infection Research, Braunschweig, Germany

    Survival of Mycobacterium bovis in protozoa
    Cornelia Mardare, Frans de Leij & Jeremy W Dale. University of Surrey, Guildford

  • AFC Summer 2007 meeting

    AFC Summer 2007

    Held at Churchill campus, University of Oxford

    July 6th 2007

    Scientific Programme

    Session 1
    BCG-MVA85A vaccination in humans: polyfunctional nature of antigen 85A-specific CD4+ T cell populations
    Beveridge NER, Price DA, Casazza JP, Pathan AA, Sander CR, Asher TE, Ambrozak DR, Precopio ML, Scheinberg P, Alder NC, Roederer M, Koup RK, Douek DC, Hill AVS, McShane H. Oxford University

    Control of gene expression in Mycobacterium tuberculosis by the SenX3 RegX3 two component system
    Jade James and Tanya Parish. Barts and the London

    Protection imparted by anti-IL-4 antibody in a murine model of M. tuberculosis infection: a potential immunotherapeutic agent?
    E Roy, J Brennan, DB Lowrie & S Jolles. Cardiff University

    Studying the soj gene of Mycobacterium tuberculosis
    Rosangela M. Frita, Farahnaz Movahedzadeh, Annemieke ten Bokum, Neil G. Stoker. The Royal Veterinary College

    An ABC transporter required for sugar uptake and virulence in Mycobacterium tuberculosis
    Rachael Whalan and Roger Buxton. National Institute for Medical Research

    Session 2

    Quantification of global transcription patterns in Mycobacterium tuberculosis
    Sidders, B., Wernisch, L., Withers, M., Kendall, SL., Cox, RA., Frita, R., Ten Bokum, A. and Stoker, NG. The Royal Veterinary College

    Mycolic-acid specific T cell responses as a marker of tuberculosis
    Montamat-Sicotte D, Millington K, Willcox C, Besra G, Innes J, Hackfoth S, Lammas D, Willcox B, Lalvani, A. Imperial College London

    Regulation of narK2 and Mb1767 genes in M. bovis and M. tuberculosis
    Christian Palavecino and Tanya Parish. Barts and the London.

    Exploring intracellular M. tuberculosis transcriptomes from human dendritic cell and macrophage infection models
    SJ Waddell, M Withers, L Tailleux, N Stoker, O Neyrolles & PD Butcher. St George’s University of London

  • AFC Winter 2007 meeting

    AFC Winter 2007

    Held at St Mary’s campus, Imperial College, London

    January 12th 2007

    Scientific Programme

    Pre-meeting session

    Discussion on withdrawal of Hycolin
    Led by Ann Rawkins

    Session 1
    Frequency of Mycobacterium tuberculosis antigen specific IFN-γ-secreting T cells correlates with presence of pathology in tuberculosis
    Timothy S.C. Hinks, Davinder P.S. Dosanjh, John A. Innes, Geoffrey Pasvol, Sarah Hackforth, Hansa Varia, Xiao-Qing Liu, Kerry A. Millington, Rubamalar Gunatheesan, Valerie Guyot-Revol, JonathanJ. Deeks & Ajit Lalvani. Tuberculosis Immunology Group, Imperial College London

    Plant Expression and Production Methodologies for Recombinant TB antigiens: Scientific and Strategic Considerations for Ensuring Affordable Product Access for Poorer Populations in Need
    Julian Ma and Harry Thangaraj. Centre for Management of Intellectual Property in Health R&D, Oxford

    A new perspective on mycobacterial cell wall biosynthesis and the identification of potential drug targets
    Luke J. Alderwick, Mathias Seidel, Lothar Eggeling & Gurdyal S. Besra. School of Biosciences, The University of Birmingham

    Isoniazid assisted protective immunity in bovine tuberculosis
    Dean GS, Rhodes SG, Wheeler PR, Villareal-Ramos B, Vordermeier HM. TB Research Group, VLA Weybridge

    A novel transcriptional regulator of PE/PPE genes of Mycobacterium tuberculosis contributes to disease immunopathology
    Sunali D. Goonesekera, Barry R. Bloom, Douglas B. Young, Samantha L. Sampson. Centre for Molecular Microbiology and Infection, Imperial College London

    Session 2

    Philip D’Arcy Hart memorial
    Philip Draper on Behalf of the Acid fast Club

    Neutrophil-mediated innate immune resistance to mycobacteria
    Adrian R. Martineau Sandra M. NewtonKatalin A. WilkinsonBeate Kampmann Bridget M. Hall Niga Nawroly, Geoffrey E. Packe Robert N. Davidson Christopher J. GriffithsRobert J. Wilkinson. Wellcome Trust Centre for Research in Clinical Tropical Medicine, Imperial College London

    Arabinosyl transferases in Mycobacterium tuberculosis
    Renan Goude & Tanya Parish. Centre for Infectious Disease, Barts and the London

    Brewing up resistance!
    Claire Jenkins, Joanna Bacon, Catherine Arnold, Alpana Bose, Jon Allnutt, Ellie Shaw, Tim McHugh & Stephen Gillespie. Royal Free & University College Medical School, London, NW3 2QG

  • AFC Summer 2006 meeting

    AFC Summer 2006

    Held at CEPR, Health Protection Agency, Porton Down

    July 13th-14th 2006

    Scientific Programme

    Session 1: CEPR TB Programme
    Overview of TB Research at CEPR
    Philip Marsh

    Guinea pig aerosol infection models in TB research
    Ann Rawkins

    Analysis of physiology and gene expression of M. tuberculosis grown in continuous culture
    Joanna Bacon

    From genes to vaccines: candidate selection and evaluation
    Julia Vipond

    Establishment of a non-human primate model of tuberculosis
    Sally Sharpe

    Session 2: Guest speakers

    Transcriptomic analysis of host-pathogen interactions
    Philip Butcher, Simon Waddell. St George’s University of London

    Diagnostic and therapeutic potentials of antibodies for the control of tuberculosis
    Juraj Ivanyi, Kings College London

    Investigation of mechanisms of protection of recombinant viral vectors containing antigen 85A in a murine model
    Clare Sander, University of Oxford

    Session 3: Offered papers

    The role of GlnE in Mycobacterium tuberculosis
    Paul Carroll and Tanya Parish, Barts and the London, QM

    Arylamine N-acetyltransferase, in mycobacteria, is a novel target for anti-TB therapy
    Sanjib Bhakta, Isaac M. Westwood, Matthew C. Anderton, Angela Russell, Hilary Long, Gurdyal Singh Besra, Ajit Lalvani, Tanya Parish, Steve Davies, Edith Sim. Department of Pharmacology, University of Oxford.

    Reassessment of optimal tuberculin skin test cut-off points for diagnosis of M. tuberculosis infection
    Davinder Dosanjh, Mustafa Bakir, Jon Deeks, Ahmet Soysal, Kerry Millington, Yasemin Aslan, Serpil Efe, Imogen Staveley, Katie Ewer, Ajit Lalvani. Tuberculosis Immunology Group, University of Oxford

    Lipid body-positive populations of tubercle bacilli in sputum – persisters responsible for protracted therapy?
    Anna L Sherratt, Natalie J Garton, Rebecca J Smith, Robert C Free, Claire Senner, Jason Hinds, Kumar Rajakumar, Richard A Adegbola, Gurdyal S Besra, Philip D Butcher and Michael R Barer. University of Leicester

    A transcriptomic approach for studying the activation of dendritic cells in response to mycobacterial infection
    N Krishnan, J Brennan, M Yang, R Butler, R S Buxton, M Romano and R E Tascon. Division of Mycobacterial Research, MRC NIMR

    Session 4: Offered papers

    Mycobacterium tuberculosis chaperonin 60.1 influences the formation of granulomas in vivo.
    Yanmin Hu, B Henderson, P Tormay, H Liu, P Lund, A Coates. Medical Microbiology, St George’s, University of London.

    Structure and function of arylamine N-acetyltransferase of Mycobacterium marinum
    Elizabeth Fullam, Sanjib Bhakta, Matthew Anderton, Angela Russell, Steve Davies, Martin Noble, Edith Sim. Department of Pharmacology, University of Oxford

    Dynamic relationship between IFN-γ and IL-2 profile of Mycobacterium tuberculosis-specific T cells and antigen load during and after treatment of active tuberculosis
    K.A. Millington, T.S.C. Hinks, J.A. Innes, S. Hackforth, J.J. Deeks, P. Klenerman and A. Lalvani. Tuberculosis Immunology Group, University of Oxford

    Comparison of fluoroquinolone activites in a Durban study of serial sputum cfu counts
    Rustomjee R, Fourie B, Davies G, Levin J and Mitchison DA. Medical Microbiology, St George’s, University of London.

  • AFC Winter 2006 meeting

    AFC Winter 2006

    Held at The Royal Free Hospital, London

    January 20th 2006

    Scientific Programme

    Session 1
    Markers of Treatment Response in Pulmonary Tuberculosis
    Felicity Perrin, Yasmin Parsons, Clare Ling, Tim McHugh, Marc Lipman & Stephen Gillespie. Centre for Medical Microbiology, UCL, London

    Macrophages undergo caspase-independent cell death after infection with M. tuberculosis
    M.P. O’Sullivan, S. O’Leary , D. Kelly, A. ten Bokum & J. Keane. Institute of Molecular Medicine, Trinity College & St James Hospital, Dublin

    Proteomic comparison of Mycobacterium avium subspecies paratuberculosis grown in vitro and isolated from clinical cases of ovine paratuberculosis
    V.M. Hughes, S, Smith, A. Garcia-Sanchez & K Stevenson. Moredun Research Institute, Edinburgh

    Transmission of M. tuberculosis undetected by PPD skin testing
    S.T.B. Anderson,S.M. Newton, J.R. Brown, A. Williams, R.N. Davidson, M. Nicol, M.Levin, R.J.Wilkinson & K.A.Wilkinson. Department of Paediatrics, Imperial College, London.

    A new tool for studying the immune response of the guinea pig model of tuberculosis
    Julia Tree, Michael Elmore, Ann Williams & Philip Marsh. Centre for Emergency Response and Preparedness, Health Protection Agency, Salisbury

    Boosting of T cell responses in either BCG vaccinated or latently infected with mycobacterium tuberculosis subjects using MVA expressing 85A – results of phase I trials
    A.A. Pathan, C.R. Sander, N. Beveridge, H.A. Fletcher, F. Gleeson, R.J.O. Davies, G. Pasvol, A.V.S. Hill & H. McShane. Centre for Clinical Vaccinology and Tropical Medicine, University of Oxford, Oxford

    Session 2

    Immune responses induced by infant BCG vaccination in Malawi and the UK
    M.K. Lalor, A.Ben-Smith, R.E.Weir, P.Gorak-Stolinska, S. Floyd, K.Makamo, R. Blitz, H.Mvula, M.J.Newport, K. Branson, A. Jahn, A.C.Crampin, P.E.Fine & H.M.Dockrell. London School of Hygiene & Tropical Medicine, London

    Isoprenoid biosynthesis in Mycobacterium tuberculosis- a potential new drug target?
    Amanda Brown, Matthias Eberl,  Tanya Parish, Barts & the London, QMSMD, London

    Sputum induction as a non-invasive method of detecting clinically elevant immune responses in all patients with tuberculosis
    RAM Breen, GA Hardy, I Cropley, G Janossy & MCI Lipman. Depts Thoracic & HIV Medicine, Royal Free Hospital. London

    Ecotypes of the M. tuberculosis complex
    Noel H. Smith, Kristin Kremer, Jacqueline Inwald, James Dale, Jeffrey R. Driscoll, Stephen V. Gordon, Dick van Soolingen, R. Glyn Hewinson & John Maynard Smith. Veterinary Laboratories Agency, Addlestone, Surrey.

  • AFC Summer 2014 meeting (60th anniversary)

    AFC Summer 2014

    60th Anniversary meeting, Berlin

    July 10-11 2014

    Scientific Programme

    Session 1: Berlin + Aeras Special

    TB Research in Berlin Spanning 130 Years
    Stefan Kaufmann, Max Planck Institute for Infection Biology

    Interferons, Inflammation and Lung Injury in TB
    Anca Dorhoi, MPIIB

    Molecular profiling for host biomarker discovery in health and disease
    Jeroen Maertzdorf, MPIIB

    Individuality in disease: patient-specific and cell-specific gene expression in TB
    January Weiner, MPIIB

    Session 2: Offered papers

    Metabolic models of mycobacteria: systems insights into pathogenesis
    Johnjoe McFadden, University of Surrey

    Transcriptome analysis reveals differential innate immune response of bovine macrophages to strains of the Mycobacterium tuberculosis complex
    Kevin Rue-Albrecht, David A. Magee, Kevin M. Conlon, Nicolas C. Nalpas, John A. Browne, Paul A. McGettigan, Claire Healy, Kirsten E. McLoughlin, Eamonn Gormley, David E. MacHugh and Stephen V. Gordon, University College Dublin

    Tetrahydrobiopterin production by macrophages is not required for protective immunity to Mycobacterium tuberculosis
    Elena Stylianou, Eileen McNeill, Rachel Kandt, Keith Channon, Helen McShane, The Jenner Institute, University of Oxford

    A brief history of the Acid Fast Club
    Ann Rawkins, Public Health England, Porton Down

    Session 3: Offered papers

    Degradosome as one of the major RNA processing complexes in mycobacteria
    Przemyslaw Plocinski, Maria Macios, Emilia Niemiec, Joanna Houghton, Douglas Young and Andrzej Dziembowski, Institute of Biochemistry and Biophysics Polish Academy of Sciences

    NO biomarker for TB –  Expired nitric oxide and lipid body content of tubercle bacilli in sputum
    Baye Gelaw, Natalie J. Garton, Gashaw Mesele,Tadye Abeje, Salie Ayalew, Pranabashis Haldar, Abraham Assefa, and Michael R Barer, Department of Medical Microbiology, CMHS, UOG, Ethiopia

    Whole genome sequencing of Mycobacterium tuberculosis from sputum: a revolution in diagnostic microbiology
    Amanda Claire Brown and members of the PathSeek project consortium, Oxford Gene Technology

    Characterisation of host genetic factors that influence pathogen-host interplay during Mycobacterium tuberculosis infection
    K. M. Kreutzfeldt, L. Mullen, C. Finan, S. J. Waddell, A. Marchant, M. J. Newportand S. M. Sacre, Brighton & Sussex Medical School, University of Sussex

    The use of gene expression profiling in Mycobacterium tuberculosis as a tool to study drug efficacy and action
    Dimitrios Evangelopoulos, Aidan Hanrath,Iva Treveska, Magdalena Karlikowska, Isobella Honeyborne, Sanjib Bhakta, Simon Waddel, Philip Butcherand Timothy D. McHugh, Centre for Clinical Microbiology, Royal Free Campus, University College London

    Session 4: Offered papers

    Development of a BCG challenge model for the testing of vaccine candidates against bovine tuberculosis
    Villarreal-Ramos, B., Berg, S., Chamberlain, L., McShane, H., Hewinson, R. G., Clifford, D., Vordermeier, M., Bovine TB Group, AHVLA, Weybridge, New Haw, Surrey

    Metabolite-Regulated Shutdown of Efflux Pumps is Critical for Mycobacterial Survival in Non-Permissive Growth Conditions
    Obolbek Turapov, Simon J Waddell, Asel Sarybaeva, Bernard Burke, Sarah Glenn, Griselda Tudo, Gilles Labesse, Danielle I. Young, Michael YoungPeter W. Andrew, Philip D. Butcher, Martin Cohen-Gonsaud,Galina V. Mukamolova, Department of Infection, Immunity and Inflammation, University of Leicester

    Redefining the mechanism of action of D-cycloserine in Mycobacterium tuberculosis
    Gareth A. Prosser, Luiz Pedro Carvalho, National Institute for Medical Research, The Ridgeway, Mill Hill, London

    AZALEP A randomized controlled trial of azathioprine to treat leprosy nerve damage and reactions in India: main findings
    Lockwood DNJ, Darlong J, Pichimani G, Royce KK, Sundar Rao, Annamma John, London School of Hygiene & Tropical Medicine, London

    A guide to killing your host cell, by Mycobacterium tuberculosis
    Graham Stewart, Robert Francis, Rachel Butler, Tom Mendum, Shaza Felemban, University of Surrey

    Meeting programme details Word file

     

  • AFC Summer 2005 meeting

    AFC Summer 2005

    Held at the University of Birmingham Medical school

    July 15th 2005

    Scientific Programme

    Session 1

    mycoDB: an online resource for mycobacterial genomics
    Roy Chaudhuri, Birmingham University

    Intranasal IFN-gamma extends the period of passive protection by IgA anti-acr mAB in Mycobacterium tuberculosis aerosol infected BALB/c mice
    Rajko Reljic, Ann Williams, Simon Clark, Stephan Challacombe, Philip Marsh, & Juraj Ivanyi, Guys Hospital Campus, Kings College London

    VNTR/MIRU typing of M. tuberculosis: a useful tool in TB control?
    Krishna K Gopaul, Timothy J Brown, Andrea L Gibson, Malcolm D Yates & Francis A Drobniewski, HPA, Mycobacterium Reference Unit, London

    A prospective study of paradoxical reactions in tuberculosis patients
    RAM Breen, F Perrin, JP Dilworth, I Cropley, MA Johnson & MCI Lipman. Depts of Thoracic & HIV Medicine, Royal Free Hospital, London

    The α-crystallin-like acr gene is responsible for hypervirulence in an Mycobacterium tuberculosis ΔdosR mutant
    Yanmin Hu , Farahnaz Movahedzadeh , Neil G. Stoker & Anthony R. M. Coates. Dept Medical Microbiology, St George’s University of London and the Royal Veterinary College

    Session 2

    Development of a Detection System to Identify TB-specific CD8 T-cell Responses Induced by Vaccination with BCG and Boosted with a Recombinant Viral Vector
    Kathryn T Whelan, Clare R Sander, Ansar A Pathan, Helen A Fletcher, Tamara K Berthoud, Adrian VS Hill & Helen McShane, University of Oxford

    Rapid identification of Mycobacterium tuberculosis (MTC) and non-tuberculosis (NTB) in a routine diagnostic laboratory
    Kerry J. Williams, Clare Ling, Claire Jenkins, Stephen H Gillespie & Timothy D. McHugh. Centre for Medical Microbiology, Hampstead Campus, UCL

    How does anti-TNF-α treatment in patients with autoimmune disease lead to increased susceptibility to tuberculosis?
    Newton S.M., Mackie S., Martineau A.R., Wilkinson K.A, Fischer C., Dhutta S., Kampmann B., Levin M., Wilkinson R.J. & Pasvol G. Wellcome Centre for Clinical Tropical Medicine, Imperial College

    Detection of bovine tuberculosis in spill-over hosts
    Jahans KL, Worth D, Brown J & Monies RJ. Veterinary Laboratories Agency, Addlestone, Surrey