AFC Summer 2000

Held at The John Radcliffe Hospital, Oxford

July 9th 2000

Scientific Programme

Session 1

A mechanism for CD8+ T cell mediated suppression of intracellular mycobacterial growth
R Brookes, H McShane, N Goonetilleke, A Lalvani, AA Psthan, DA Price, GM Griffiths & A Hill.  Oxford University

OmpATb – a pore-forming protein of M. tuberculosis and how it may be regulated
R Speight & P Draper. NIMR

An increase in expression of a M. tuberculosis mycolyl transferase gene (fbpB) occurs early after infection of human monocytes
RJ Wilkinson¹²³, LE DesJardin², BM Gibson², KA Wilkinson¹, D Poleman¹, RA Kanost¹, KD Eisenach², Z Toossi².  ¹Division of Infectious Diseases, Case Western Reseve University, Cleveland, Medical Research Service. ²JL McClellan Memorial Veterans’ Administration Hospital, Little Rock. ³Wellcome Centre for Clinical Tropical Medicine, Imperial College of Medicine, Northwick Park Hospital

Genetic Transformation of Mycobacterium paratuberculosis
S Thorne & JJ McFadden.  University of Surrey

Role of heat shock proteins in inflammation: M. tuberculosis chaperonin 60.1 (hsp60) is a more potent cytokine-stimulator than chaperonin 60.2 (hsp65) and contains a cryptic CD14-binding domain
JC Lewthwaite, ARM Coates, S Kahn, M Singh, P Mascagni, S Poole, M Roberts & B Henderson.  Eastman Dental Institute and St George’s Hospital Medical School

The use of recombinant viruses as tuberculosis vaccines
N Goonetilleke, R Anderson, H McShane, S Gilbert, R Brookes & A Hill.  Oxford University

Session 2

Crystal Structure of Mycobacterium tuberculosis Chaperonin 10
M Roberts, AR Coker, ARM Coates and SP Wood.  St George’s Hospital Medical School and Southampton University

Growth control and dormancy in Mycobacterium smegmatis
R Wright, J Dickinson, S Thorne, M Bushell & JJ McFadden.  University of Surrey

Protection against tuberculosis in a prime-boost regime is mediated by one CD4+ and one CD8+ T cell epitope
H McShane, S Behboudi, N Goonetilleke, S Gilbert, R Brookes & A Hill.  Oxford University

Comparative studies of defined skin test antigens in M. bovis infected guinea pigs and cattle
AO Whelan, HM Vordermeier & RG Hewinson.  VLA Weybridge

Stressed up, Messed up: De-regulation of HSP70 response in Mycobacterium tuberculosis
G Stewart, V Snewin, P Tormay, P O’Goara, M Goyal, I Brown & DB Young.  Imperial College of Medicine at St Mary’s Hospital

AFC Winter 2000

January 7th 2000

Scientific Programme

Session 1

Shedding light on immunity to mycobacteria
VA Snewin, DJ Turner, M-P Gares and DB Young

Rapid detection of M. tuberculosis infection by enumeration of antigen specific T cells.
Ajit Lalvani, Ansar A Pathan, Helen McShane, Robert J Wilkinson, Mohammed Latif,
Christopher P Conlon, Geoffrey Pasvol & Adrian VS Hill

Generation of mycobacterial mutants using plasmid incompatibility
C. Pashley, RA McAdam, K Duncan, T Parish, NG Stoker

Do chemokines differ in skin lesions across the leprosy spectrum?
AA Kirkaldy, S Khanolkhar-Young, S Suneetha & D Lockwood

The Biology of Anti-tuberculosis Drug Resistance
Stephen H Gillespie , Owen Billington, Timothy D McHugh

Session 2

Plasmid Transfer from Streptomyces to Mycobacteria smegmatis
Apoorva Bhatt and Tobias Kieser

Differential Trafficking of the Mycobacterium tuberculosis 19 kDa antigen and access to the MHC Class I processing Pathway
Olivier Neyrolles, Marie-Pierre Gares, Keith Gould, Sara Brett, Peadar O’Gaora, Marie-Christine Prevost, Emmanuelle Perret, Riny Janssen, Jelle Thole & Douglas Young

Pre-BCG Immune Responses to Mycobacterial Antigens in a Malawian Population
Gill Black

Demonstration of adherence of mycobacteria to a human respiratory tissue organ culture by electron microscopy
AM Middleton, MV Chadwick, AJ Nicholson, A Dewar, R Wilson

The study of environmentally regulated genes in mycobacteria species using bioluminescence
Jamila Shafi, Peter Andrew, Kenneth Duncan & Ruth McAdam

Examination of clinical and archaeological material using PCR primers that can detect low levels of Mycobacterium leprae DNA
Helen D Donoghue, John M Holton and Mark Spigelman