INSTITUT PASTEUR de LILLE
AFC 70th Anniversary (Summer) meeting 2022
2nd & 3rd July 2024
Programme of speakers, associates, affiliations and presented titles
Speakers are indicated in Bold
2nd July 2024
Welcome by AFC Chair, Michael Barer
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Host Keynote Presentation: Camille Locht, Institut Pasteur de Lille
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Session 1: Selected papers from submitted abstracts
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Galleria mellonella as a model for phase therapy for mycobacteria.
Ben Swift, Lily Brown, Cath Rees, Albert Huynh, Mas Asai.
Royal Veterinary College.
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The use of sputum mimetic media to replicate conditions in the cystic fibrosis lung alters antibiotic susceptibility in Mycobacterium abscessus complex.
Emily Baker, Antonia Molloy, Gemma Allcott, Jonathan Cox.
Aston University.
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Oxysterol 25-hydroxycholesterol is a key metabolic immunomodulatory and a target for host-directed therapy against tuberculosis.
Khushboo Borah Slater, Luciana Rodrigues, Brian Robertson, Johnjoe McFadden, Tiffany Xu, Holly May-Lewis, Alex Steward, Helen Griffiths, Andriy Mohkir, Selin Roman.
University of Surrey.
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Do defensins defend against TB?
Joshua Rosenheim, Mahdad Noursadeghi.
University College London.
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Session 2: Selected papers from submitted abstracts
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Mycobacterium avium paratuberculosis: is it a ‘One Health’ pathogen to be reckoned with?
Philip A. Robinson.
Harper & Keele Veterinary School.
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New facets of transcriptional and translational control in Mycobacterium tuberculosis.
Peter Polgar, Alex D’Halluin, Terry Kipkorir, Declan Barker, Alan Joy, Kristine Arnvig.
University College London.
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Factors associated with immunogenicity of BCG revaccination and of ChAdOx1 85A-MVA85A: a longitudinal follow up of Ugandan adolescents from birth.
Beatrice Nassanga, Emily L. Webb, Jacent Nassuuna, Esther Imede, Joyce Kabagenyi, Gloria Oduru, Gyaviira Nkurunungi, Angela Nalwoga, Anne Wajja, Joel Sserubanja, Agnes Natukunda, Helen Akurut, Hazel Morrison, Hannah Scott, Julia L. Marshall, Ingrid Carbrera Puig, Rebecca Powell Doherty, Stephen Cose, Pontiano Kaleebu, Obondo Sande James, Irene Andia Biraro, Iman Satti, Helen McShane, Alison Elliott.
University of Oxford, UK and Makerere University, Uganda.
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Single particle – inductively coupled plasma – mass spectrometry (SP-ICP-MS): A powerful tool to study metals during host-pathogen cell interactions.
Claire Davison, Jordan Pascoe, Melanie Bailey, Dany Beste, Mónica Felipe-Sotelo.
University of Surrey.
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Characterisation of local immune response to Mycobacterium tuberculosis in pulmonary granulomas from experimentally infected rhesus macaques.
Laura Hunter, Suzie Hingley-Wilson, Graham Stewart, Sally Sharpe, Javier Salguero.
UK Health Security Agency & University of Surrey.
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3rd July 2024
Keynote Presentation: BCG – New insights on an old vaccine. Helen McShane, University of Oxford.
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Session 3: Selected papers from submitted abstracts
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Elucidating the role of cAMP in Mycobacterium abscessus in response to short chain fatty acids.
Claudia Blanco-Toral, Christopher Guilhot, Christian Chalut, Ione Goodwin, Ella Marshall, Yi Liu, Marc Dionne, Gerald Larrouy-Maumus.
Imperial College London.
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Investigating the effect of nitrosative stress on the metabolomic profile of differentially culturable mycobacteria.
Emily Milburn, Helen O’Hare, Natalie Allcock, Gerald Larrouy-Maumus, Galina Mukamolova.
University of Leicester.
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Diagnostic performance of 6-mRNA loop-mediated isothermal amplification assay for rapid diagnosis of childhood tuberculosis disease in an African multi-country cohort.
Giselle D’Souza, K. Malpartida-Cardenas, L. Miglietta, O’ Vito, L. Workman, S. Nichols, L. Estramiana-Elorrieta, S. T. Anderson, A. J. Brent, B. Eley, M. P. Nicol, G. Walzl, S. M. Newton, B. Kampmann, H. J. Zar, V. J. Wright, M. Kaforou, M. Levin, J. Rodriguez-Manzano
On behalf of the ILULU and NIH TB paediatric consortium. Imperial College London.
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Characterising lung mucosal and systematic immune response in an aerosol BCG human challenge model using single cell sequencing.
Shuailin Li, Hazel Morrison, Julia Marshall, Mihaela Duta, Mirvat Surakhy, Stephanie Harris, Alberta Ateere, Beatrice Nassanga, Elena Stylianou, Iman Satti, Helen McShane.
University of Oxford.
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Session 4: Selected papers from submitted abstracts
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Dissecting vitamin B12 transport in mycobacteria.
Terry Kipkorir.
London School of Hygiene and Tropical Medicine.
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In vitro models of mycobacterial survival during transmission focussing on bovine tuberculosis, desiccation and bacterial lipid bodies.
Valeria Quimper, Georgia Osborn, Natalie Garton, Mike Barer.
University of Leicester.
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Mycobacterium tuberculosis uses lipid remodelling to overcome phosphate starvation during infection of the host.
Robert Gray, Mariana Silva Dos Santos, Acely Garza-Garcia, Deborah Hunt, Aleksandra Agapova, James MacRae, Jiuyu Liu, Richard Lee, Luiz Pedro Sorio de Carvalho.
The Francis Crick Institute, Imperial College London & University College London.
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Acetylation of DosR by the lysine acetyltransferase Rv0998 regulates the glucose metabolism of Mycobacterium tuberculosis under acidic pH.
Yi Liu, Nadia Fernandes, Valwynne Faulkner, Richard Williams, Eachan Johnson, Sandhya Visweswariah, Brian Robertson, Gerald Larrouy-Maumus.
Imperial College London.
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IgG glycosylation associates with risk of progression from latent to active tuberculosis.
Matthew O’Shea, Julie G Burel, Wenjun Wang, Manfred Wuhrer, Martin Dedicoat, Thomas E Fletcher, Adam F Cunningham.
University of Birmingham.
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Keynote Presentation: Red Dragons, White Plague. Glyn Hewinson, Aberystwyth University.
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Session 5: Selected papers from submitted abstracts
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How does Mtb survive early bactericidal activity?
Frank Kloprogge, Arundhati Maitra, Celeste Watson, Isabelle Papandronicou, Dimitrios Evangelopoulos, Graham Bothamley, Timothy McHugh.
The Francis Crick Institute, Imperial College London & University College London.
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Profiling the genomic architecture of the transcriptional response to tuberculosis treatment.
John Francis O’Grady, Alexander S. Leonard, Houcheng Li, Lingzhao Fang, Hubert Pausch, Isobel C. Gormely, David E. Machugh.
University College Dublin.
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Characterising the PknG activation complex.
Hannah Tompkins, Helen O’Hare, Russell Wallis.
University of Leicester.
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Altered IL-6 signalling and risk of tuberculosis disease: a multi-ancestry Mendelian randomisation study.
Gabriele Pollara, Fergus Hamilton, Haiko Schurz, Tom A. Yates, James J. Gilchrist, Marlo Möller, Vivek Naranbhai, Peter Ghazal, Nicholas J. Timpson; Genes & Health Research Team, International Host TB Genetics Consortium, Tom Parks.
University College London.