AFC Winter 2003

January 2003

Scientific Programme

Session 1

TB imaging- a new way forward?
Satya Das, KE Britton, DW Wareham (introduced by Tanya Parish)

The SenX3 RegX3 two component regulatory system of Mycobacterium tuberculosis.
Gretta Roberts, Debbie Smith, Jo Betts, Neil Stoker, Tanya Parish

Increased mRNA encoding IL-4d2 and IL-4 in unstimulated peripheral blood mononuclear cells from those TB contacts whose cells release IFN in response to ESAT-6
Helen Fletcher, Roger Brookes, Patrick Owiafe, Philip Hill, Mark Doherty, Graham Rook, Alimuddin Zumla & the VACSELstudy group

The cAMP receptor protein (CRP) of Mycobacterium tuberculosis: effect of a null mutation in this global regulator
Lisa Rickman, Jeffrey Green, Colin Scott, Jo Colston and Roger Buxton

Naturally acquired sensitivity to PPDs of environmental mycobacteria among UK school children^.
Rosemary Weir, Paul Fine, Bernadette Nazareth, Sian Floyd, Gillian Black, Carolynne Stanley, Lyn Bliss, Keith Branson, and Hazel M. Dockrell

Is there a major endemic of tuberculoid leprosy in Central America?
John L Stanford and Helen D Donoghue on behalf of the Nicaragua Study Group Leprosy in Nicaragua

Session 2

What pathogenic mycobacteria want- amino acid biosynthesis and availability in the host.
Paul Wheeler, Lisa Keating, Esen Wooff, Steve Gordon, Tanya Parish and Glyn Hewinson

Roles of Serine/Threonine protein kinases in M. tuberculosis pathogenicity.
K. G. Papavinasasundaram, Bosco H. Y. Chan, Elaine O. Davisand M. Joseph Colston

Induction by Mycobacterium vaccae and its components of regulatory mechanisms involving IL-10 and TGF-β that suppress allergic responses
L. Rosa Brunet, C. Zuany-Amorim, E. Sawicka, C. Manlius, A. Le Moine, V. Adams, B. Palmer, J. Hunt, G.S. Besra, C. Walker, G. Rook

Mycobacterium tuberculosis sigJ knockout alters sensitivity of slow- growing bacteria to hydrogen peroxide
Yanmin Hu, Sharon Kendall, Neil Stoker, Anthony Coates

Effector memory CD8 T cells are associated with long-term immune control of M. tuberculosis.
Kazi F, Prakash M, Ewer K, Waller S, Varia H, Pasvol G & Lalvani A

Koch’s Bacillus – A look at the first isolate of M. tuberculosis from a modern perspective.
Taylor GM, Stewart GR, Cooke M, Ladva, S, Young DB